5.1. The Meeting recommended (Section 2.2) that WHO establishes a Working Group, including scientists who have helped develop the concepts of the acute RfD at the JMPR, to develop further guidance on how to interpret existing databases, including single-dose studies and early data from repeated-dose studies, and how to perform single-dose studies in relation to establishing an acute RfD.
5.2. The Meeting recommended (Section 2.4) that the Project to Update the Principles and Methods for the Risk Assessment of Chemicals in Food should
give clear general principles for risk assessment procedures;
include guidance for special toxicological considerations, such as the acute RfD;
give general guidance for analytical methods, including fitness for purpose, sampling, and quality assurance;
give clear guidance for exposure assessment, including assessment of acute exposures,
include clear description, with uncertainties, of the process by which maximum residue limits (MRLs) are recommended;
for residues of pesticides and veterinary drugs, where harmonization of certain risk assessment approaches may not be possible, give clear, transparent justifications for the differences.
5.3. The Meeting recommended (Section 2.5) selective surveys to provide data for estimating maximum residue levels for spices when adequate monitoring data are unavailable and recommended some guidelines for the selective surveys.
5.4. The Meeting recommended (Section 2.9) steps to improve the estimates of dietary intake. Immediate refinements are:
introduce the proposed 13 sub-regional diets.
increase the availability of large portion sizes and unit weights data, especially from developing countries.
Additional improvement steps recommended are:
evaluate processing studies submitted to JMPR over the last decade to ascertain if default processing factors are feasible for some processes and/or if processing data can be extrapolated to related processes.
refine generic and commodity-specific variability factors used in the short-term intake calculations.
elaborate procedures for probabilistic modelling at the international level.
5.5. The Meeting recommended (Section 2.12) implementation of a pilot project on worksharing. The test compound will be trifloxystrobin at the 2004 JMPR.
5.6. The Meeting recommended (Section 2.13) implementation of a pilot project to apply the recommendations of the York Workshop and the Zoning Report and recommended that FAO initiate the project and recommend a compound suitable for the pilot project in 2004.
5.7. The Meeting recommended (Section 3) that pirimiphos-methyl, carbendazim and thiophanate-methyl should be evaluated for the establishment of acute RfDs in the near future.
