45. The FAO and WHO Joint Secretaries of JECFA summarized the results of the 52nd (February 1999) and 54th (February 2000) meetings of JECFA.
46. Seven substances were evaluated toxicologically at the 52nd meeting, the b-adrenoceptor blocking agent carazolol, the antimicrobial agent thiamphenicol, the insecticide phoxim, and four production aids (estradiol-17b, progesterone, testosterone, and porcine somatotropin). An acute reference dose on the basis of pharmacological activity was allocated to carazolol, and acceptable daily intakes (ADIs) were allocated to the other six substances.
47. Five substances were evaluated toxicologically at the 54th meeting, the antimicrobial agent lincomycin, three insecticides (cyhalothrin, dicyclanil, and trichlorfon (metrifonate)), and the production aid melengestrol acetate. A temporary ADI was allocated to cyhalothrin and ADIs were allocated to the others.
48. At the 52nd meeting, JECFA recommended 31 MRLs for five substances: doramectin in pig tissues, dihydrostreptomycin and streptomycin in cattle, pig, sheep and chicken, neomycin in cattle liver and kidney tissues and deltamethrin in cattle, sheep and chicken. Twenty-three temporary MRLs were recommended for dihydrostreptomycin/streptomycin in cattle milk, thiamphenicol in pig tissues and fish muscle and phoxim in cattle, pig, sheep and chicken tissues, muscle of salmon and cattle milk. Guidance MRLs were recommended for deltamethrin in muscle tissue of cattle, sheep, chicken and salmon as well as cattle milk and chicken eggs (see also para. 77). JECFA recommended that the temporary MRLs for thiamphenicol in cattle and chicken be withdrawn. MRLs for estradiol-17b, progesterone and testosterone were recommended as “not specified”.
49. At the 54th meeting, JECFA recommended 27 MRLs for four substances: flumequine in cattle, pig, sheep and chicken tissues and muscle tissue of trout, lincomycin in pig tissues and cattle milk, dicyclanil in sheep tissues and for trichlorfon (metrifonate) in cattle milk. Twenty-nine temporary MRLs were recommended for: ivermectin in cattle milk, lincomycin for cattle, sheep and chicken tissues, oxytetracycline for fish muscle, cyhalothrin in cattle, pig and sheep tissues and cattle milk and melengestrol acetate in cattle liver and fat. JECFA recommended that the temporary MRLs for tilmicosin in sheep milk be withdrawn as well as the temporary MRLs for á-cypermethrin and cypermethrin in cattle, sheep and chicken tissues, cattle milk and chicken eggs. Guidance MRLs were recommended for trichlorfon (metrifonate) in cattle tissues.
50. To improve harmonization with JMPR and transparency of the risk assessment procedures in JECFA, reports[12] on the JECFA responses to the 1999 JECFA/JMPR Informal Harmonization Meeting and the JECFA Procedures for Recommending Maximum Residue Limit - Residues of Veterinary Drugs in Food, were completed at the 54th JECFA and forwarded to CCRVDF for consideration.
