Today’s society faces many challenges when it comes to food production: producing food sustainably, producing enough of it, distributing food, consuming enough calories, consuming too many calories, consuming culturally-appropriate foods, and reducing the amount of food wasted. The distribution of power within the current mainstream agri-food system is dominated by multinational agri-businesses that control the flow of goods and wealth through the system. This hegemony has implemented a regime whose structures reinforce its control. A growing response to the current agri-food regime is the rise of agroecology, in both developed and developing country contexts. This is not a new phenomenon, but it has evolved over time from its Latin American origins. However, agroecology is not a monolithic block and represents many different perceptions of what it means to advance agroecology and ways in which it can help today’s society tackle the crisis of the agri-food system. This paper addresses these sometimes discordant view points, as well as the gaps in our knowledge regarding agroecology in an effort to lay out some guiding principles for how we can move forward in transforming the current agri-food system to achieve sustainability and a more equitable distribution of power and resources.