Even before the pandemic struck, the ambitious path that was laid out by the Sustainable Development Goals (SDGs) was going to require a concerted effort to stay on track; COVID-19 has fundamentally changed the context in which Agenda 2030 was being pursued and we now risk a reversal of gains made in the last few years. The poorest and most vulnerable groups will experience the most negative effects of the current pandemic. This demographic includes subsistence farmers as well as smallholder farmers’ enterprises. This policy brief is intended for decision-makers in developing Member Countries where food security and nutrition are underpinned by the outputs of hundreds of millions of smallholder farmers. It provides guidance on actionable measures for mitigating the effects of the COVID-19 pandemic on crop production to support sustainable food systems, and ultimately enhancing the resilience of institutions and infrastructure to ensure delivery of safe and nutritious food.