This case study, Effectiveness and duplicability of the Youth Inspiring Youth in Agriculture (YIYA) initiative, is an output deriving from the assessment of the YIYA Initiative in Uganda. In 2017, the Food and Agriculture Organization of the United Nations (FAO) and the Government of Uganda, with the Ministry of Agriculture, Animal Industry and Fisheries (MAAIF) as a lead counterpart agency, implemented the YIYA initiative, a youth agribusiness competition programme, with the objective of promoting youth agripreneurship. The YIYA is an approach to fostering lead youth agripreneurs as “mentors” for other youth. This case study summarizes the YIYA programme assessment, which was conducted with a view to proposing recommendations for the duplication of the YIYA or the implementation of similar youth agribusiness competition programmes in other countries.