Theobroma cacao (cocoa) is an ecologically beneficial crop in tropical agroecosystems, and can serve as a cash crop for farmers in developing countries. The growing demand for cocoa products coupled with increasing disease pressures has led to the concept that enhanced germplasm with disease tolerance and high yields could dramatically impact the lives of cocoa farmers in a positive way. Utilization of such cocoa trees will increase cocoa-farming profitability, promoting expanded and sustainable production. Methods have been developed to enhance the development of cocoa germplasm and its deployment through the combined approaches of biotechnology, applied horticulture and technology transfer. The following describes the macro propagation method which is a very low-cost method with very high multiplication rate.