Two years have passed since the United Nations Decade of Family Farming 2019-2028 (UNDFF) began. During these two years, two important observations have been made: the first is the enormous capacity of family farming to create alliances, and the second is the comprehensive and coherent response that the Decade can provide to current major global challenges. In this sense, the World Rural Forum (WRF) aimed to invite people to reflect on the keys to the large-scale implementation of the United Nations Decade for Family Farming at a Global Conference entitled "Family Farming at the Core of Sustainable Food Systems", which was held between 22 and 26 November 2021. The Global Conference was conceived as a high-level platform to raise the relevance of family farming in relation to the achievement of sustainable, resilient, inclusive and viable food systems, within the framework of the UNDFF 2019-2028, and to stimulate concrete commitments in favour of the 2.5 billion people who depend on family farming activities worldwide.