Skills for work are undoubtedly a transformative force for Latin America and the Caribbean. The developed countries' experience has shown that when a country's labor force responds efficiently to the human capital needs of companies and the economy, labor productivity is boosted leading to higher and sustainable economic growth. Through the TVET Fund, IDB is promoting innovative solutions and demonstrating how skills systems can take advantage of the opportunities presented by the fourth industrial revolution, gender and diversity, ageing, climate change and COVID-19, which will be essential in achieving a sustainable and equitable future in the region. This dossier contains 17 initiatives that show how to unlock talent using, for example, artificial intelligence to guide job retraining, introducing modern courses to offer training in green skills, and training programs to facilitate remote work and meet the increasing demand for digital services globally.