This publication outlines key features of South-South and Triangular Cooperation (SSTC) and how FAO has applied SSTC to the delivery of its mission. The case studies presented provide a window on how SSTC has contributed to alleviating hunger and malnutrition in countries across the global South and has helped build resilience in the face of climate change and other development challenges. The lessons learned from these experiences are feeding into the new FAO SSTC Guidelines for Action (2022–2025) and will guide FAO's future results-based SSTC programmes.