Fish is important for good nutrition and fishery activities generate income and employment. However, industrial and intensive fishing and also wrong fishing methods deplete fish stocks. In Uganda, the major fishing activities are on Lake Victoria, one of the African great lakes and the second largest in the world. These activities provide employment, income, and export earnings to the communities living around the lake. Lake Victoria fishing is a mainly commercial fishery and needs to be well managed in order to make it sustainable and preserve the commercial fish species. The National Fisheries Resources Research Institute (NaFIRRI), as one of the established Public Agricultural Research Institutes, generates knowledge base and develop fisheries technologies for increased but sustainable fish production, conservation of the fisheries genetic resources, water quality, and fish habitat. It ensures product dissemination and quality, develop and manage research and required linkages with stakeholders. Below is some advice they give for fisher communities and fishery managers for sustainable commercial fishery management on Lake Victoria.