European Research and Innovation Days is the European Commission’s annual flagship Research and Innovation event, bringing together policymakers, researchers, entrepreneurs and the public to debate and shape the future of research and innovation in Europe and beyond. 2022 was the fourth edition. The event took place on 28 and 29 September and attracted almost 14 000 participants from over 100 countries. This conference report contains summaries, quotes and images from the tw odays event. You are welcome to explore all live sessions and workshops on EU Science & Innovation YouTube channel.