FAO organized its first ever Global Conference on Sustainable Plant Production (GPC) (Rome, 2 to 4 November 2022), with a focus on Innovation, Efficiency and Resilience. Its main objective was to provide a neutral forum for FAO Members, farmers, scientists, development agencies, policy makers, extensionists, civil society, opinion leaders and the private sector to engage in dialogues around sustainable plant production. To achieve impact towards implementing the 2030 Agenda, the GPC developed 20 actionable recommendations. The recommendations encompass all the thematic areas highlighted in the GPC, with a focus on adaptation to local contexts, needs of small-scale farmers, and include cross-cutting issues to guide active innovation for global sustainable plant production systems. The recommendations clearly establish (i) priorities for targeted mobilization and pooling of scientific, technical and financial resources; (ii) evidence and knowledge sharing through the creation and management of functional technical networks; and (iii) testing and scaling evidence-based sustainable plant production practices, partnerships and policies.