Water scarcity threatens irrigated agriculture in sub-Saharan Africa (SSA). Knowledge of farmers’ perceptions and drivers for decision-making in view of coping with water scarcity is so far lacking but needed to improve local technologies and frame policies fostering their adoption. Here, for the first time, we investigated farmers’ perception of water scarcity, key adaptation strategies, and the determinants of their adoption in irrigated rice schemes in dry climatic zones of West Africa. We surveyed 572 farming households and conducted expert interviews with key informants in four contrasting irrigated rice schemes in Burkina Faso between April 2018 and August 2019. Information was gathered on biophysical field characteristics, grain yields, agronomic and water management practices, farmers’ perception of water scarcity, their adaptive responses, and social-economic attributes of adopting households. Nearly 80% of the respondents reported having experienced water scarcity during the past 5 years. To cope with the adverse effect of water scarcity, farmers implemented seventeen different adaptation strategies that could be categorized into seven groups. Most popular among those were “water and soil conservation practices” (consisting mainly of field bunding and leveling), “no rice cultivation,” and “crop rotation.” Farmers in drier areas (Sudano-Sahelian zone) were less likely to adopt and implement several adaptation strategies to water scarcity compared to farmers in wetter areas (Sudanian zone). Belonging to farming associations increased the probability of implementing several strategies to alleviate water scarcity, while female-headed households tended to have a lower propensity to adopt and implement concomitantly several adaptation strategies in comparison with their male counterpart. The dissemination of scheme- and household-specific technology options could contribute to mitigating water scarcity in irrigated rice-based systems in the dry climatic zones of West Africa, thus contributing to rural livelihood and food security.