Sand and dust storms (SDS) are common in drylands with dust often transported over great distances, frequently across international boundaries. Such storms are important for ecosystem functioning, but they also create numerous hazards to society, in agriculture and other socioeconomic sectors. The yields and productivity of crops, trees, pastures and livestock are adversely affected by SDS. With climate change it is expected that droughts and land use changes will increase the frequency and risk of SDS. While agriculture is a major driver of SDS, agriculture is impacted by SDS and it is also part of the solution to combat SDS risks and mitigate their impacts. This guide aims to provide an overview of sand and dust storms and the impacts on agriculture and food systems. It gives a review of how agriculture can create SDS sources and highlights the impacts of SDS on agricultural production in source and deposition areas. It includes a range of high-impact, location- and context-specific practices to reduce SDS source and impacts on agriculture subsectors at local level, comprising technical and non-technical interventions. Moreover, it assesses how SDS risk is addressed at the policy level and discusses options for integrating SDS at national and regional levels into multi-hazard disaster risk reduction (DRR) and disaster risk management (DRM) strategies or sectoral development programmes, followed by conclusions and recommendations. Urgent action must be taken now. Short-term responses need to be linked to long-term development actions to enhance combating SDS. The adverse impacts of SDS are likely to become even more severe in the future, particularly due to climate change, unless appropriate interventions are made.