The United Nations Sustainable Development Cooperation Framework (“Cooperation Framework”) is an agreement between the UN and the host government and determines a country’s development priorities as well as the UN development system’s contributions to them. As AMR hinders progress in many of the Sustainable Development Goals (SDGs), coordinated action across UN organizations and government agencies is needed to effectively tackle AMR across all sectors. A new guidance for UN country teams builds the case for AMR as a development issue and component of broader issues such as One Health, UHC and health security, food systems and planetary health: it aims to establish AMR as a higher priority on the policy and development agenda; stimulate multi-stakeholder interest; and attract funding.