Potato is a major food crop in the mid-hills and mountains in Nepal. Traditionally, most farmers use small tubers as seed, to grow potato with the minimum input. Although seed tubers are easy to plant and plants grow quickly, they are expensive and may account for more than half of the total production costs. Also, seed tubers are the main carriers of diseases and pests; they are perishable; bulky; and difficult to transport. In addition, seed tubers require costly refrigerated storage facilities to prevent rotting in storage and to keep them in adequate physiological conditions until the next planting season. Conventional varieties grown by local farmers, such as Kufri, Cardinal, Kufri jyoti, and Kufri Sindhuriare are susceptible to late blight and vulnerable to low temperatures, leading to poor yields. Potato production from True Potato Seed (TPS) is more advantageous than using “seed potatoes”. By planting true potato seeds, farmers maintain genetic diversity that will protect the production from any new pest, disease, or changes in climate or cultural practices.