The urgent need for a positive impact on the livelihoods of livestock keepers is elaborated in this Regional Strategy for Animal Health and Production for FAO Regional Office for Europe and Central Asia (REU). This strategy aims to present the main aspects of REU’s work on livestock and includes three pillars – animal health, animal production, and antimicrobial resistance (AMR) – along with seven cross-cutting issues, among them gender, environmental sustainability, community farming as a business, and coordination with other international organizations. The strategy follows FAO’s commitment to the UN 2030 Sustainable Development Goals (SDGs) through continuous and dedicated work towards the improvement of animal health and productivity while reducing the threat of AMR using the One Health approach.