Since 2004, the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) have cooperated in the Global Framework for the Progressive Control of Transboundary Animal Diseases (GF-TADs) to reduce the threat from transboundary animal diseases (TADs) to food security, livelihoods and safe trade. The GF-TADs is a coordination mechanism established to safeguard its Members from repeated incursions of infectious animal disease epidemics, to enhance safe trade in animals and animal products, and to improve food and nutrition security by reducing the damaging effects of TADs. To reach these long-term goals, the GF-TADs Strategy for 2021−2025 aims to enhance the control of TADs through the establishment of priority TADs strategies at the regional and sub-regional level, by developing the capacity to prevent and control TADs, and by improving the sustainability of priority TADs strategies through multi-disciplinary partnerships. The ultimate goals of the global strategy are to improve food security and nutrition, to reduce poverty and to enhance safe trade in livestock and animal products by reducing repeated incursions and the further spread of infectious disease epidemics. The GF-TADs Strategy was developed through a ‘Theory of Change’ model and is described as a series of objectives. Chapters describe the management of the GF-TADs Strategy, resource mobilization and a framework for monitoring and evaluation, with clear indicators. In addition, the strategy provides an overview of the GF-TADs governance model and its global priority diseases.