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Online Edition: "Residues of some veterinary drugs in foods and animals"

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This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.

Veterinary Drug Neomycin
Functional class Antimicrobial agent
Latest evaluation 2003
JECFA meeting 60
ADI 0-60 µg/kg bw
ADI status Full
Residue monographs  
Marker residue Parent drug
Maximum residue limits
(MRL) recommended
CattleFat500 µg/kgF
CattleKidney10000 µg/kgF
CattleLiver500 µg/kgF
CattleMilk1500 µg/kgF
CattleMuscle500 µg/kgF
ChickenEggs500 µg/kgF
ChickenFat500 µg/kgF
ChickenKidney10000 µg/kgF
ChickenLiver500 µg/kgF
ChickenMuscle500 µg/kgF
DuckFat500 µg/kgF
DuckKidney10000 µg/kgF
DuckLiver500 µg/kgF
DuckMuscle500 µg/kgF
GoatFat500 µg/kgF
GoatKidney10000 µg/kgF
GoatLiver500 µg/kgF
GoatMuscle500 µg/kgF
PigFat500 µg/kgF
PigKidney10000 µg/kgF
PigLiver500 µg/kgF
PigMuscle500 µg/kgF
SheepFat500 µg/kgF
SheepKidney10000 µg/kgF
SheepLiver500 µg/kgF
SheepMuscle500 µg/kgF
TurkeyFat500 µg/kgF
TurkeyKidney10000 µg/kgF
TurkeyLiver500 µg/kgF
TurkeyMuscle500 µg/kgF
Other remarks
Summary of the evaluation Committee considered the following factors in recommending MRLs:
- An ADI of 0 - 60 mg/kg bodyweight based on a toxicological end-point, which results in a maximum daily intake of 3600 mg for a 60 kg person.
- Neomycin undergoes negligible metabolism following parenteral administration in animals and the parent drug represents the total of the residues present in the tissues.
- Neomycin is the marker residue for tissues, milk and eggs.
- A validated HPLC method with a LOQ of 0.1 mg/mL for neomycin in cow's milk is available and is suitable for routine use.
- Concentrations of neomycin up to 2 mg/l had no effect on bacterial starter cultures used in the production of fermented milk products.
- Data on residues in milk supported an MRL for cow's milk of 1500 mg/kg.
- Information on the registered use patterns for injectable formulations of neomycin in food-producing animals was requested from Governments and considered. The information indicated that use of parenteral formulations is not regarded as good practice in the use of veterinary drugs, and few such products were found to be approved.
- The MRLs for kidney of 20000 mg/kg and for liver of 15000 mg/kg recommended by the Committee at its 52nd Meeting to accommodate use of parenteral formulations are therefore unnecessary.
The Committee, having considered the data submitted since its 43rd meeting, decided to revert to the MRLs for cattle kidney and liver that it had recommended at its 47th meeting.
Based on the consumption of 300 g of muscle, 100 g of liver, 50 g of kidney, 50 g of fat, 1.5 kg of milk and 100 g of eggs, the theoretical maximum daily intake of neomycin residues is 3025 mg. This accounts for 84 % of the ADI of 3600 mg for a person of 60 kg bodyweight.
FNP 41/15