Food safety and quality
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Online help Terminology
This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.
Veterinary Drug |
Neomycin |
Functional class |
Antimicrobial agent |
Latest evaluation |
2003 |
JECFA meeting |
60 |
ADI |
0-60 µg/kg bw |
ADI status |
Full |
Residue monographs |
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Marker residue |
Parent drug |
Maximum residue limits (MRL) recommended |
Cattle | Fat | 500 µg/kg | F | Cattle | Kidney | 10000 µg/kg | F | Cattle | Liver | 500 µg/kg | F | Cattle | Milk | 1500 µg/kg | F | Cattle | Muscle | 500 µg/kg | F | Chicken | Eggs | 500 µg/kg | F | Chicken | Fat | 500 µg/kg | F | Chicken | Kidney | 10000 µg/kg | F | Chicken | Liver | 500 µg/kg | F | Chicken | Muscle | 500 µg/kg | F | Duck | Fat | 500 µg/kg | F | Duck | Kidney | 10000 µg/kg | F | Duck | Liver | 500 µg/kg | F | Duck | Muscle | 500 µg/kg | F | Goat | Fat | 500 µg/kg | F | Goat | Kidney | 10000 µg/kg | F | Goat | Liver | 500 µg/kg | F | Goat | Muscle | 500 µg/kg | F | Pig | Fat | 500 µg/kg | F | Pig | Kidney | 10000 µg/kg | F | Pig | Liver | 500 µg/kg | F | Pig | Muscle | 500 µg/kg | F | Sheep | Fat | 500 µg/kg | F | Sheep | Kidney | 10000 µg/kg | F | Sheep | Liver | 500 µg/kg | F | Sheep | Muscle | 500 µg/kg | F | Turkey | Fat | 500 µg/kg | F | Turkey | Kidney | 10000 µg/kg | F | Turkey | Liver | 500 µg/kg | F | Turkey | Muscle | 500 µg/kg | F |
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Other remarks |
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Summary of the evaluation |
Committee considered the following factors in recommending MRLs: - An ADI of 0 - 60 mg/kg bodyweight based on a toxicological end-point, which results in a maximum daily intake of 3600 mg for a 60 kg person. - Neomycin undergoes negligible metabolism following parenteral administration in animals and the parent drug represents the total of the residues present in the tissues. - Neomycin is the marker residue for tissues, milk and eggs. - A validated HPLC method with a LOQ of 0.1 mg/mL for neomycin in cow's milk is available and is suitable for routine use. - Concentrations of neomycin up to 2 mg/l had no effect on bacterial starter cultures used in the production of fermented milk products. - Data on residues in milk supported an MRL for cow's milk of 1500 mg/kg. - Information on the registered use patterns for injectable formulations of neomycin in food-producing animals was requested from Governments and considered. The information indicated that use of parenteral formulations is not regarded as good practice in the use of veterinary drugs, and few such products were found to be approved. - The MRLs for kidney of 20000 mg/kg and for liver of 15000 mg/kg recommended by the Committee at its 52nd Meeting to accommodate use of parenteral formulations are therefore unnecessary. The Committee, having considered the data submitted since its 43rd meeting, decided to revert to the MRLs for cattle kidney and liver that it had recommended at its 47th meeting. Based on the consumption of 300 g of muscle, 100 g of liver, 50 g of kidney, 50 g of fat, 1.5 kg of milk and 100 g of eggs, the theoretical maximum daily intake of neomycin residues is 3025 mg. This accounts for 84 % of the ADI of 3600 mg for a person of 60 kg bodyweight. FNP 41/15 |
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