Inocuidad y calidad de los alimentos
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Ayuda en línea Terminology
Esta base de datos contiene la información más reciente sobre los niveles máximos de residuos en drogas veterinarias según lo recomendado por JECFA. Todas las monografías publicadas en la FAO sobre Alimentación y Nutrición, Papeles 41, son accesibles en formato electrónico. Estas monografías están sólo disponibles en inglés aunque algunas partes de la base de datos, como la página de preguntas y también una información básica se puede encontrar en árabe, chino, español, francés e inglés.
Medicamento veterinario |
Fenbendazole |
La clase funcional |
Antiparasitic |
Ultima evaluación |
1998 |
Reunión de JECFA |
50 |
IDA |
0-7 µg/kg bw |
Estatus de IDA |
Full |
Monografías de residuos |
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Definición del residuo |
Sum of fenbendazole+oxfendazole+oxfendazole sulfone, expressed as oxfendazole sulfone equivalents |
Límites máximos para residuos (LMR) recomendados |
Cattle | Fat | 100 µg/kg | F | Cattle | Kidney | 100 µg/kg | F | Cattle | Liver | 500 µg/kg | F | Cattle | Milk | 100 µg/l | F | Cattle | Muscle | 100 µg/kg | F | Goat | Fat | 100 µg/kg | F | Goat | Kidney | 100 µg/kg | F | Goat | Liver | 500 µg/kg | F | Goat | Muscle | 100 µg/kg | F | Horse | Fat | 100 µg/kg | F | Horse | Kidney | 100 µg/kg | F | Horse | Liver | 500 µg/kg | F | Horse | Muscle | 100 µg/kg | F | Pig | Fat | 100 µg/kg | F | Pig | Kidney | 100 µg/kg | F | Pig | Liver | 500 µg/kg | F | Pig | Muscle | 100 µg/kg | F | Sheep | Fat | 100 µg/kg | F | Sheep | Kidney | 100 µg/kg | F | Sheep | Liver | 500 µg/kg | F | Sheep | Milk | 100 µg/l | F | Sheep | Muscle | 100 µg/kg | F |
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Otras observaciones |
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El resumen de la evaluación |
In reaching its decision on MRLs for febantel, fenbendazole and oxfendazole, the Committee took into account the following factors: - An ADI of 0-7 µg per kg of body weight was established. This would result in a maximum ADI of 420 µg for a 60 kg person. - The data on metabolism, pharmacokinetics and residue depletion are similar in cattle, sheep, goats, pigs and horses. - The correlation between residues in plasma and milk is similar in sheep and cows. - The data on analytical performance provided by the sponsor show that the highest limit of quantification for any of the edible tissues or milk is well below the recommended MRLs. - The residues in tissues and milk in all species are calculated as oxfendazole sulfone equivalents. - The MRLs are expressed as the sum of the three principal metabolites (fenbendazole, oxfendazole and oxfendazole sulfone), calculated as oxfendazole sulfone equivalents. The MRLs would result in a maximum daily intake of 240 µg of residues of febantel, fenbendazole and oxfendazole, based on a daily food intakeof 300 g of muscle, 100 g of liver, 50 g each of kidney and fat, and 1.5 l of milk. TRS 888 |
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