Sécurité sanitaire et qualité des aliments
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Aide en ligne Terminology
Cette base de données contient l'information la plus récente sur les niveaux de résidus maximum pour les médicaments vétérinaires recommandés par JECFA. Toute la documentation publiée dans l'étude FAO Alimentation et Nutrition No. 41 est disponible en ligne en format numérique. Cette documentation existe seulement en Anglais, tandis que les pages d'information générale et une partie de la base de données sont traduites en Anglais, Français, Espagnol, Arabe et Chinois.
Médicament vétérinaire |
Fenbendazole |
Classe fonctionnelle |
Antiparasitic |
Dernière évaluation |
1998 |
Réunion de JECFA |
50 |
DJA |
0-7 µg/kg bw |
Statut de la DJA |
Full |
Monographies des résidus |
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Définition du résidu |
Sum of fenbendazole+oxfendazole+oxfendazole sulfone, expressed as oxfendazole sulfone equivalents |
Limites maximales de résidu (LMR) recommandés |
Cattle | Fat | 100 µg/kg | F | Cattle | Kidney | 100 µg/kg | F | Cattle | Liver | 500 µg/kg | F | Cattle | Milk | 100 µg/l | F | Cattle | Muscle | 100 µg/kg | F | Goat | Fat | 100 µg/kg | F | Goat | Kidney | 100 µg/kg | F | Goat | Liver | 500 µg/kg | F | Goat | Muscle | 100 µg/kg | F | Horse | Fat | 100 µg/kg | F | Horse | Kidney | 100 µg/kg | F | Horse | Liver | 500 µg/kg | F | Horse | Muscle | 100 µg/kg | F | Pig | Fat | 100 µg/kg | F | Pig | Kidney | 100 µg/kg | F | Pig | Liver | 500 µg/kg | F | Pig | Muscle | 100 µg/kg | F | Sheep | Fat | 100 µg/kg | F | Sheep | Kidney | 100 µg/kg | F | Sheep | Liver | 500 µg/kg | F | Sheep | Milk | 100 µg/l | F | Sheep | Muscle | 100 µg/kg | F |
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Autres remarques |
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Résumé de l'évaluation |
In reaching its decision on MRLs for febantel, fenbendazole and oxfendazole, the Committee took into account the following factors: - An ADI of 0-7 µg per kg of body weight was established. This would result in a maximum ADI of 420 µg for a 60 kg person. - The data on metabolism, pharmacokinetics and residue depletion are similar in cattle, sheep, goats, pigs and horses. - The correlation between residues in plasma and milk is similar in sheep and cows. - The data on analytical performance provided by the sponsor show that the highest limit of quantification for any of the edible tissues or milk is well below the recommended MRLs. - The residues in tissues and milk in all species are calculated as oxfendazole sulfone equivalents. - The MRLs are expressed as the sum of the three principal metabolites (fenbendazole, oxfendazole and oxfendazole sulfone), calculated as oxfendazole sulfone equivalents. The MRLs would result in a maximum daily intake of 240 µg of residues of febantel, fenbendazole and oxfendazole, based on a daily food intakeof 300 g of muscle, 100 g of liver, 50 g each of kidney and fat, and 1.5 l of milk. TRS 888 |
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