Food safety and quality: details

兽药

Fenbendazole

功能分类

Antiparasitic

最新评价

1998

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-7 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

41-4-fenbendazole.pdf

41-8-fenbendazole.pdf

41-11-febantel_fenbendazole_oxfendazole.pdf

残留标示物

Sum of fenbendazole+oxfendazole+oxfendazole sulfone, expressed as oxfendazole sulfone equivalents

建议的最高残留限量

Cattle	Fat	100 µg/kg	F
Cattle	Kidney	100 µg/kg	F
Cattle	Liver	500 µg/kg	F
Cattle	Milk	100 µg/l	F
Cattle	Muscle	100 µg/kg	F
Goat	Fat	100 µg/kg	F
Goat	Kidney	100 µg/kg	F
Goat	Liver	500 µg/kg	F
Goat	Muscle	100 µg/kg	F
Horse	Fat	100 µg/kg	F
Horse	Kidney	100 µg/kg	F
Horse	Liver	500 µg/kg	F
Horse	Muscle	100 µg/kg	F
Pig	Fat	100 µg/kg	F
Pig	Kidney	100 µg/kg	F
Pig	Liver	500 µg/kg	F
Pig	Muscle	100 µg/kg	F
Sheep	Fat	100 µg/kg	F
Sheep	Kidney	100 µg/kg	F
Sheep	Liver	500 µg/kg	F
Sheep	Milk	100 µg/l	F
Sheep	Muscle	100 µg/kg	F

其他说明

评价概要

In reaching its decision on MRLs for febantel, fenbendazole and oxfendazole, the Committee took into account the following factors:
- An ADI of 0-7 µg per kg of body weight was established. This would result in a maximum ADI of 420 µg for a 60 kg person.
- The data on metabolism, pharmacokinetics and residue depletion are similar in cattle, sheep, goats, pigs and horses.
- The correlation between residues in plasma and milk is similar in sheep and cows.
- The data on analytical performance provided by the sponsor show that the highest limit of quantification for any of the edible tissues or milk is well below the recommended MRLs.
- The residues in tissues and milk in all species are calculated as oxfendazole sulfone equivalents.
- The MRLs are expressed as the sum of the three principal metabolites (fenbendazole, oxfendazole and oxfendazole sulfone), calculated as oxfendazole sulfone equivalents.
The MRLs would result in a maximum daily intake of 240 µg of residues of febantel, fenbendazole and oxfendazole, based on a daily food intakeof 300 g of muscle, 100 g of liver, 50 g each of kidney and fat, and 1.5 l of milk.
TRS 888

网络版“:食品和家畜中的一部分兽药残留”