Food safety and quality: details

兽药

Lincomycin

功能分类

Antimicrobial agent

最新评价

2004

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-30 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

41-16-lincomycin.pdf

41-13-lincomycin.pdf

41-14-lincomycin.pdf

残留标示物

Parent drug

建议的最高残留限量

Cattle	Milk	150 µg/kg	F
Chicken	Fat	100 µg/kg	F
Chicken	Kidney	500 µg/kg	F
Chicken	Liver	500 µg/kg	F
Chicken	Muscle	200 µg/kg	F
Pig	Fat	100 µg/kg	F
Pig	Kidney	1500 µg/kg	F
Pig	Liver	500 µg/kg	F
Pig	Muscle	200 µg/kg	F

其他说明

A separate MRL of 300 mg/kg for skin with adhering fat in pigs was recommended in order to reflect the high concentrations found in the skin of pigs. For consistency, an MRL of 300 mg/kg for skin with adhering fat in chickens was also recommended.

评价概要

In reviewing the MRLs recommended at its fifty-fourth meeting, the Committee at its present meeting took into account the following factors:
- The ADI of 0-30 mg/kg bw allocated by the Committee at its fifty-fourth meeting was based on a microbiological end-point. This ADI is equivalent to an acceptable maximum daily intake of 1800 µg of antimicrobially active residues of lincomycin for a 60 kg person.
- Parent lincomycin is the only residue with significant antimicrobial activity in tissues of chickens and pigs.
- Kidney and liver contain the highest concentrations of residues in chickens and pigs and pid=63155; however, the new studies confirmed that the concentrations of residues in kidney and liver are similar in chickens, but differ by a factor of three in pigs.
- The new studies suggest that the MRLs for skin/fat of chickens and for muscle of pigs should be higher than those recommended at the fifty-fourth meeting. The MRLs for fat could be maintained for bot hspecies, provided that a separate MRL was recommended for skin with adhering fat in pigs in order to reflect the high concentrations found in the skin of that species.
- For residue control programmes, it would be appropriate to harmonize the MRLs for chicken and pig tissues as far as possible.
- The temporary MRLs for tissues of cattle and sheep should be withdrawn, as the requested information was not provided.
- No data were provided on lincomycin residues in hen's eggs.
Daily consumption of 100 g of liver, 50 g of kidney, 300 g of muscle and 50 g of fat of pigs and 1500 g of cow's milk would result in a theoretical maximum daily intake of 415 µg per person per day or 23% of the ADI for a person with a body weight of 60 kg.
TRS 911

网络版“:食品和家畜中的一部分兽药残留”