The presence of mycotoxins in grains and other staple foods and feedstuffs has serious implications for human and animal health. Many countries have enacted regulations stipulating maximum amounts of mycotoxins permissible in food and feedstuffs. Most developed countries will not permit the import of commodities containing amounts of mycotoxins above specified limits. Mycotoxins therefore have implications for trade between nations. Prevention of fungal invasion of commodities is by far the most effective method of avoiding mycotoxin problems. Mycotoxin considerations should be a component of an integrated commodity management program focusing on the maintenance of commodity quality from the field to the consumer.