The FAO-WFP Hunger Hotspots report is a forward-looking, early warning analysis of countries and situations, called hotspots, where acute food insecurity is likely to deteriorate over the coming months. These hotspots are identified through a consensus-based analysis of key drivers of food insecurity, and their likely combination and evolution across countries and regions. Looking at the outlook period of March–July 2021, there are 20 countries and situations where there is a likelihood of further deterioration in acute food insecurity, due to multiple drivers of hunger that are interlinked or mutually reinforcing. These are primarily conflict dynamics, economic shocks, the socio-economic impacts of COVID-19, weather extremes and the diffusion of plant pests and animal diseases. The report provides country-specific recommendations on priorities for emergency response, as well as anticipatory action to address existing humanitarian needs and ensure short-term protective interventions before new needs materialize. These actions are strongly recommended to save lives, protect the livelihoods of the most vulnerable populations and prevent further human suffering.