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PPR GEP Secretariat is housed at the Headquarters of the Food and Agriculture Organization of the United Nations (FAO) and comprises two individuals jointly agreed by FAO and OIE to be responsible for the overall coordination and management for converting the Global Control and Eradication Strategy into the Global Eradication Programme and its implementation, assessment, refinement and reporting. 

The Secretariat reports to the Global Framework for the Progressive Control of Transboundary Animal Diseases (GF-TADs) Management Committee for guidance and coordination with other GF-TADs initiatives. It also reports to the co-chairs of the Steering Committee of the GF-TADs (OIE Director General and Director Animal Production and Health Division of FAO). 

Tasks of the PPR GEP Secretariat are to prepare annual and five-year plans for endorsement by the GF-TADs Global Steering Committee; to prepare and seek clearance for a calendar of events and to provide guidance to the FAO/OIE decentralized offices and Regional GF-TADs Secretariats on the implementation of the endorsed annual plan and the annual calendar of events.

PPR GEP Secretariat also facilitates coordination and promotes implementation of the PPR GEP at global, regional and country levels; works to communicate the progress made towards eradication and advocates for the PPR GEP i.e. representing FAO/OIE at international, regional and national meetings, identifying partners/areas for complementarity and recommending, when needed, appropriate collaborative actions.

The Secretariat is also responsible for the overall management and implementation of the programme, the liaison with OIE and FAO reference centres on PPR, small ruminant production and health, applied diagnostic and epidemiological themes and vaccine production in support of the implementation of the PPR GEP.