This report is based on a study in response to the BMG Foundation’s approach to investing in sustainable agricultural productivity growth, which centers on integrating investments along the entire agricultural value chain from “molecule” (e.g., investments into plant research and development) to “mouth” (investments that connect farmers to consumers). This study aims to inform practitioners to make better decisions on how to prioritize research, increase farmers’ market access, and address policy constraints through a better understanding of the dynamics of the sweetpotato sub-sector in West Africa, through a combined market demand and value chain study.