Thriving ecosystems are well-managed ecosystems. They provide essential benefits and services to people who have access to green spaces. Nature-based solutions, such as green interventions at urban level, can address public health related issues. However, knowledge on the effectiveness of green interventions in terms of human health, well-being and equity is not well understood. The Nature’s Impact on Human Health Guide can play a vital role in determining the effectiveness of green interventions in promoting human health. This Guide, in fact, was created to help practitioners and community leaders seeking to evaluate the human health impacts resulting from nature-based (“green”) interventions. The basis for the Guide is a customizable bank of survey questions, a reporting template for conveying the survey results, and helpful background information and guidance on how to do community-based research.