In Medellin, the City Food Region System implemented a few years ago, enabled local producers, consumers and local government to keep an active food distribution system. Overall, the program generates income for producers, lowers the costs of supplying vendors and ensures a secure channel of food supply during the crisis. Local authorities also experimented innovative distribution channels. In the midst of the COVID-19 crisis, the territorial perspective and the concept of city region food systems, recently included in the city's food and nutrition security programs, are significantly contributing to developing an approach to respond to the crises.