Unleashing the potential for inclusive agricultural growth and transformation in Africa requires coordinated and strategic public and private investment in the agriculture sector. Against a background of limited government resources and expertise, public–private partnerships are increasingly being promoted as a mechanism to pool resources, reduce risk, improve productivity and drive growth in the agriculture and food sectors. In line with this trend, many African countries have recently expressed an interest in further understanding the potential for public–private partnerships for agribusiness development (agri-PPPs) to deliver on these transformative goals. This publication aims to provide guidance to African policymakers and potential private sector investors on the core principles of designing and implementing agri-PPPs that will promote the transformation of Africa’s agriculture sector in an inclusive and sustainable way. This area of work is of particular interest to the African Union Commission (AUC) which has highlighted agri-PPPs as a key tool in the delivery of the results under the Comprehensive Africa Agricultural Development Programme (CAADP) and the Malabo Declaration on Accelerated Agricultural Growth for Shared Prosperity and Livelihoods.